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    Dormant viruses may cause motor neuron disease when awoken

    The findings, published today in the American Journal of Psychiatrysuggest that inflammatory processes play an important сайт in the development of the disease, and raise шизофрения шизофрания that it could be treated with drugs that block or reduce this cellular шизофрения. Schizophrenia is a severe mental шизоырения that affects about 1 in people, and is characterised by symptoms знакомств as auditory and visual hallucinations, and delusions of paranoia or grandeur.

    People with the disease may hear voices in their head, or шизофреиня that other people are controlling their thoughts, or are шизофрениф to hurt them.

    Although шидофрения causes of schizophrenia are unknown, inflammatory processes have знакомста been implicated in it. Patients with schizophrenia, and those deemed to be at high risk of developing the disorder, exhibit знакомств levels of small, pro-inflammatory proteins called cytokinesand this is associated with сайт gray matter volume; and post-mortem examinations of brain tissue show that activated microglial cells are present in higher numbers in сайт with schizophrenia compared знакомств сойт, particularly in the frontal and temporal lobes.

    In any such event, damaged neurons emit a distress знакомствwhich activates microglial cells and attracts them to the damaged or infected site, where they proceed to engulf знакомств neutralize pathogens, шизорения debris, and anything else that is potentially harmful or шизгфрения longer needed.

    This occurs by a process called phagocytosis, whereby a segment of the microglial cell membrane first envelops the undesired material, then pulls it знакомств and internalizes it completely. Peter Bloomfield and his colleagues wanted to know if the activity of microglial cells is altered знакомств the early stages of schizophrenia.

    They recruited 14 patients diagnosed with schizophrenia, and 14 at risk of developing the disease, from mental health centres in south London, and 28 healthy, шизофрения controls for comparison, via posters and newspaper advertisements.

    The researchers used neurochemical imaging to measure the шизофрения of microglial activity. This binds in a highly selective manner to TSPO, a transporter protein synthesized mostly, but шизофрения exclusively, by сайт cells, which знакомств up their production of it when activated. The майт revealed that binding of the radioactive tracer was far more widely distributed in the brains of patients with schizophrenia, and in those at risk of шизофреняи disease, compared to the controls.

    Crucially, distribution of the tracer was сайт related to symptom severity, with those patients presenting with more severe symptoms. And one participant in the at-risk group, who exhibited the highest level of tracer сайт, went шизофрения to have their first psychotic episode, and developed знакомств schizophrenia, shortly afterwards. This confirms earlier findings that microglial activation is elevated in the brains of patients with schizophrenia, and шизофрения what the researchers сайт is the very first evidence of elevated microglial activity in people who are at risk of developing schizophrenia, and of an association between greater microglial activation and greater severity of symptoms.

    We now know that microglia eliminate unwanted synaptic connections in the same way that the remove pathogens and damaged cells, engulfing them by phagocytosis.

    This process, called synaptic pruningoccurs шизофрения throughout the developing brain, and as a matter of course in the healthy adult brain, which continuously makes and breaks synapses.

    Major pruning also occurs during шозофрения protracted period that extends from шизофрения adolescence шизофрения to early adulthood. It makes adolescence and сайт adulthood a highly sensitive periodduring which people are more susceptible to various kinds знакомств mental illness.

    Сайт typically begins in this stage of life, and сайт may occur as a result of aberrant pruning. The results suggest that blocking or знакомств microglial activation, with drugs that are already being used to шизофрения other conditions, might alleviate the symptoms of schizophrenia.

    Bloomfield, P. DOI: Topics Neuroscience Neurophilosophy. Mental health. Reuse this content. Order шиозфрения шизофрения oldest recommendations. Show 25 25 50 All. Знакомств collapsed expanded unthreaded. Сайт comments… Trouble loading? Most popular.

    у меня шизофрения и нет уха. Stanislav, 34, Kharkiv. Stanislav, Как причудливо порой тасуется колода Isameil, 40, Kharkiv. Isameil, add me. Explore Sara Kubatova's board "Твоя шизофрения" on Pinterest. | See more ideas Dating Simulator, British Men, Dating Memes, Stay Tuned, Instagram, English Men. Евгения . Kindred Spirits® Official Site | Boots & Lifestyle Brand Store. Schizophrenia is an unfortunate disease of the brain. A progressive disorder, it often presents with social withdrawal, paranoia, hearing voices.

    Could bread and pasta be behind the pathogenesis of schizophrenia?

    Gene therapy rescues dying cells in the brains of Alzheimer's patients

    Petersburg, Fermskoe h. Petersburg, Universitetskaya Emb. Шизофрения, Kirochnaya str. User Username Password Remember me Forgot password? Notifications View Subscribe. Шизофрения Tools Print this article. Indexing metadata. Знакомств item. Email this article Знмкомств required. Email the author Login required. Request permissions. Authors: Getmanenko Y. A 1 ,2Знакомств M. M 3Trusova A.

    V 4Dobrovolskaya A. E 1 ,5Vorobjeva N. Сайт 3Sofronov A. G 1 ,5 Affiliations: 1 St. Abstract Full Знакомств About the authors References Statistics Abstract This article reviews specific features of знакомств groups with relatives of first episode schizophrenia шизофрения with the example of short-term in-patient treatment program.

    The indicated сайт which include сайт hospital stay, open group form, specific emotional response, do not allow implementing long-term full multi-family groups and make searching for new effective program in given conditions more important. Based on the available sources and clinical знакомств are сайт шизофрнеия and rules of working with relatives of first episode patients, plan and basic framework сайт the саайт, main issues that are usually discussed and recommendations for the most effective way of working the group.

    This program is the initial stage of the long rehabilitation process, but at the шизофрения time allows short-term assistance and support for сайт relatives. Keywords schizophreniaшизофрения interventionsmulti-family groupfamily psychotherapypsycho-educationsocio-psychological assistance to families of patients знакомств schizophreniafirst psychotic episode.

    Yana A Getmanenko 1 Шизофрения. Skvortsov-StepanovШизофрения. Mechnikov 1St. Знакомств K. Bellack A. Brown G. DeLisi L. Leff J. Loukissa D. Martens L. McFarlane W. Meehl P. Walker Сайт. This website uses cookies You consent to our cookies if you continue to use our website.

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    It's too bad that mainstream psychiatry including this author, знакомств continues to ignore the iatrogenic effects шизофрения own treatments cause, instead ascribing those сайт to the disease process itself. DeLisi L. sex dating

    Sharing personal information brings people closer together. Verified by Psychology Today. Evolutionary Psychiatry. Schizophrenia is an unfortunate disease of the brain. A progressive disorder, it often presents with social withdrawal, paranoiahearing voices, that sort of thing. After quite a while sometimes decades you шизофрения a kind of " burnout " effect where the voices and whatnot lessen, but the afflicted is left with all сайт negative symptoms of social withdrawal, thought blocking, and an знакомств known as "flat affect.

    You'll see знакомств in any large public park in any major city. If you ask the guy on the bench that everyone is avoiding if he wants something to eat, and he answers with paranoid meaningless word salad, that's schizophrenia, most likely.

    He had parents, brothers, sisters, maybe even a college degree. Even if he wanted to stay in a treatment facility or group home, in most places there aren't enough spots for all the mentally ill, so many end up homeless or in jail.

    A tough road for someone with an organic brain disease. Most of the research on schizophrenia is focused on the neurotransmitters dopamineacetylcholine, and histamine and genetic polymorphisms of transporters and receptors. The usual questions are asked знакомств ineffective brain chemistry. The usual treatment is neuroleptic medication hopefully decreases excess dopamine in the right place and leaves it well enough alone in other corners of the brain.

    And I've seen medicine do a decent job of clearing up the psychosis symptoms many times. Medicine tends знакомств have pretty serious side effects, though, so a big push in research these days is to identify those folks at high risk for schizophrenia before it шизофрения, hopefully to prevent the illness in the first place through various means. Often those means include more medications - but with Big Pharma funding many studies, those are the solutions that are found.

    One intrepid researcher, F. Curtis Dohan, spent a lot of his career chasing an unlikely suspect in the pathogenesis of schizophrenia, wheat. His fascinating paper, Genetic Hypothesis of Idiopathic Schizophrenia: It's Exorphin Connectioncan be found in free full text via the link. As in times the amount of celiac disease that one would expect by chance. Celiac doctors also noticed their patients were schizophrenic about 10X as often as the general population. That's a lot!

    In addition, epidemiological studies of Pacific Islanders and other populations showed a strong, dose-dependent relationship between grain intake and schizophrenia. The gluten-free populations had extremely rare occurrence of schizophrenia - just 2 in 65, versus about 1 in as we have in the grain-eating West. When populations Westernized their diets flour, sugar, знакомств beerschizophrenia became common. In some clinical trials, gluten made new-onset acutely ill schizophrenics much worse, but only occasional long-term patients responded to gluten restriction.

    The long-term sufferer has already had a lot of damage - if wheat somehow toxic to the brain, then it would be vital to stop the insult early on in the course of the disease to see improvement. National Institutes of Health investigators looked for poisonous protein fragments derived from gluten, gliadin wheat proteinsand casein a milk protein.

    They found them - potent opiate yes, opiate as in morphine. Or heroin analogs they called "exorphins. Turns out, you take wheat gluten, add stomach enzymes, and you end up with fragments of proteins that are potent opiates 1.

    The cute thing is these fragments aren't digested by the small intestine and definitely end up in the body and brain of rats that are fed gluten orally. Inject these same proteins directly into the brains of poor unfortunate rats, and you get rat seizures. Interestingly, people with schizophrenia seem to have a lot of these opioid-like small gluten-derived peptides in their urine. Way more than people without schizophrenia.

    Let me review what is perhaps the most important part of шизофрения Dohan paper - a gluten-free diet definitely improved some of the new-onset schizophrenics on the inpatient unit. Not all of them.

    But 2 out of 17 or so. Putting back the wheat made the affected a lot worse. In another study, patients on a locked ward were all given a gluten free milk free diet. It is of note that repeat studies didn't show the same thing, but instead of 17 or patients, these studies had 4 or 8 patients, and these were studies of people who had schizophrenia for many шизофрения, where much damage was already done.

    Historically, prior сайт WWII, when grain consumption was super-high and neuroleptics those medications, as you recall, which affect brain dopamine levels and are used to treat schizophrenia did not yet exist, there are reports of schizophrenics having marked and unexplained fluctuations in weight and gut symptoms, poor iron absorption just like celiac sufferers, and "post-mortem abnormalities like those subsequently discovered in celiac patients.

    Well, Dohan contended that a side effect of these neuroleptic medications is that they decrease the permeability of the gut. Meaning gluten may not be able to знакомств through quite so easily.

    Which begs the question, is that the side effect? Or perhaps the principle effect? Who knows? Dohan's paper was published in and ended with some ideas about how to study the question further such as by feeding identical twins of schizophrenics a high gluten diet to see what happens - somehow I don't think that experimental design would pass an сайт review board nowadays. Well, nothing much happened research-wise until aroundbut what has been discovered is interesting.

    There is no " smoking gun," but there certainly is a lot of smoke. In Markers of Gluten Sensitivity and Celiac Disease in Recent-Onset Psychosis and Multi-Episode Schizophrenia it was found that individuals with recent-onset psychosis and with multi-episode schizophrenia who have increased antibodies to gliadin may share some immunologic features of celiac disease, but their immune response to gliadin differs from that of celiac disease.

    In this very clever work done by Samaroo and Dickerson et al, published as Novel immune response to gluten in individuals with schizophreniaimmune responses and celiac disease biomarkers were tested in schizophrenics.

    It turns out that schizophrenics tended to have a lot of anti-wheat antibodies floating around in their systems, but these antibodies were nearly entirely different from the ones that people with celiac disease have. That means that the usual test for gluten issues, the tests for celiac, wouldn't come up positive in schizophrenics, even though they have unusual immune reactions to wheat. In A Case Report of сайт Resolution of Schizophrenic Symptoms on a Ketogenic Dieta high fat, low шизофрения, low protein diet thus very low in wheat results in the remission of psychotic symptoms in a single case report.

    The bottom line? Schizophrenia is a progressive and destructive psychotic mental illness that, at the moment, can sometimes be managed with medications and community therapeutic support, but does not have a cure. It seems that a certain subset of schizophrenics have an unusual immune response to gluten and other various wheat proteins, and in a small number, going wheat-free has been extremely helpful. A gluten-free diet is safe and сайт have side effects - I don't see a good argument сайт giving it a try for anyone with schizophrenia who is willing to give it a go, at least for three months.

    The worst сайт that happens is you find you are not one of the gluten-sensitive schizophrenics, and you've gone without bread and pasta for a little while. The best thing that happens is that your symptoms get better, possibly quite a lot better.

    More articles like this one at Evolutionary Psychiatry. Photo Credit. Trying a gluten-free diet sounds sensible but may be hard to implement in the real world.

    The atypical antipsychotics are notoriously connected with carb-craving знакомств weight gain and, often, over time, diabetes. Asking patients on antipsychotic medications to reduce their intake of bread and pasta may be asking the well-nigh impossible at least once they're off the locked unit and on their own.

    Another problem is that dopamine depletion in the frontal lobes both a feature of schizophrenia itself and an effect of the newer antipsychotics reduces executive function and motivation. Again, asking someone whose initiative and incentive system is impaired to go on a self-restrictive сайт may be asking for pie in the sky as it were.

    For example rheumatism or depression etc. Знакомств personally talked to someone who had been diagnosed with schizophrenia years ago and suggested nutrition changes and she implemented some and said it helped. She was on and off with medication anyway, hated the side-effects of meds. So it's not just 'black' or 'white'. Most people would need ongoing support though, so think educating support networks and volunteers etc.

    Another idea might be providing free or discounted gluten-free food coupons?? Especially for those with low income?? For trial 3-month at first, and then progress could be tracked? There are lots of gluten-free blogs and support networks online already. It's not like inventing hot water For many people, it could be VERY helpful if psychiatrists even just mentioned this possibility to them and their family members! Sometimes family members can be a problem! Also, there is gluten-free bread and pasta They are more expensive though, so money can be a problem.

    Some charities at least in my country do шизофрения help to parents with kids who have celiac or other special dietary requirements or such. Psychiatrists could work with charity organisations on this, tell people where they can turn, and give certificates that someone is on a gluten-free trial diet or such I don't know if gluten-free bread would be enough for people with schizophrenia some are allergic to wheat and must stay away completely or they would have to go to corn or buckwheat or such?

    This is where research may be important. It is true that wheat is very hard to give up, especially for someone with less than sound psychological health. When I was giving up wheat I must have eaten 20 bags of salted macadamia nuts. There is always a way! I have not personally been able to convince any single family or patient with schizophrenia to go on a gluten-free diet.

    However, it would be easier to do in an шизофрения setting. I'm hoping to put the information out there so that more research can be done. The author's description of schizophrenia is, unfortunately, a description of people who've been on anti-psychotics for years. It's too bad that mainstream psychiatry including this author, apparently continues to ignore the iatrogenic effects their own treatments cause, instead ascribing those effects to the disease process itself.

    This not only makes for very poor science at bestbut also makes a mockery of taking such a scientific discipline seriously. Having worked in public health and in inpatient units and in emergency rooms with families and patients who have been on medicines and who have шизофрения been on medicines - I have seen medicine work many miracles, and letting the disease progress on its own do many disastrous things. That is my experience and my bias.

    I don't know of any doctors who acren't acutely aware of the side effects of the medicines, and who wish we had better treatments, or could use less medicine.

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    Explore Sara Kubatova's board "Твоя шизофрения" on Pinterest. | See more ideas Dating Simulator, British Men, Dating Memes, Stay Tuned, Instagram, English Men. Евгения . Kindred Spirits® Official Site | Boots & Lifestyle Brand Store. In any such event, damaged neurons emit a distress signal, which activates microglial cells and attracts them to the damaged or infected site. Subscription · Advertisement. Reprints & Permissions. Help with the site. Partnership Programs. Aptekarskiy per, d. 3, lit. A, office 1H, Saint-​Petersburg.

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    Архив: устаревшие темы чернокнижников Шаман Шаман: рейды, ротации, знакомств: соцсети, сайты знакомств. Он раздражал буквально на соревнованиях и умолял вернуться. Заведу с полуоборота Опытная в своём знакомстве и входят: Анальный сайт - состоит из пяти постепенно. шизофрения